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benzodiazepines reducing the risk

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Benzodiazepines: Reducing the Risk

Benzodiazepines have a very high abuse liability, but also have strong therapeutic benefits. As such, they are used frequently, often with negative consequences for the patient. For this Discussion, consider the following questions:

  • Why is it that benzodiazepines have such high abuse potential?
  • How do the pharmacokinetics, pharmacodynamics, and response curve of benzodiazepines potentially impact their abuse potential?
  • What individual-level factors might make certain benzodiazepine users more likely to develop problematic use?

Post by Day 4 an analysis of tolerance and withdrawal of sedative hypnotics and alcohol. In your analysis, differentiate between appropriate use and misuse of sedative hypnotics and alcohol. Also, explain the impact of sedative hypnotics and alcohol on brain systems, neurotransmitters, and behavior. Finally, propose at least two ways to mitigate the abuse potential.

Readings

  • Advokat, C. D., & Comaty, J. E., & Julien, R. M. (2019). Julien’s primer of drug action: A comprehensive guide to the actions, uses, and side effects of psychoactive drugs (14th ed.). New York, NY: Worth Publishers/Macmillan.
    • Chapter 5, “Ethyl Alcohol and the Inhalants of Abuse” (pp. 135-174)
    • Chapter 13, “Anxiolytics, Sedative Hypnotics, Anesthetics, and Anticonvulsants” (pp. 489-524)
  • Hancock, S. D, & McKim, W. A. (2018). Drugs and behavior: An introduction to behavioral pharmacology (8th ed.). Upper Saddle River, NJ: Pearson.
    • Chapter 6, “Alcohol” (pp. 119-145)
    • Chapter 7, “Anxiolytics and Sedative-Hypnotics” (pp. 148-166)
  • Spinella, M. (2001). The psychopharmacology of herbal medicine: Plant drugs that alter mind, brain, and behavior. Cambridge, MA: MIT Press.
    • Chapter 7, “Psychotherapeutic Herbs” (pp. 260–277)
 
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