The Protein Project will consist of 3 parts. If you have not selected your own protein then you will be assigned a protein for completion of the project. Literature references should be included with citations to the source of material.

Part A: Protein Description and History

Identify some of the basic structure and chemical features (AA sequence, MW, pI, etc.) of your protein using the information and tools on NCBI, ExPASy, Protein Data Bank, etc. websites. (See the Resources links below.)
Give an extensive literature based overview of your protein. From journal articles determine more about the history, functions, and possible roles in cellular mechanisms. Also, explore if this protein has been linked to diseases or disorders.

Part B: Understanding the Structure & Function

Develop a set of visuals (tables, charts, images, etc.) to convey the basic information of the protein identified above (MW, pI, hydrophobicity, etc.).
Give the complete amino acid sequence for protein
Give an image of the 3-D structure and identify secondary structural features
How do the elements of the protein structure influence the function of the protein? Are there elements that could be changed and not affect the function? What are the structural elements that are required for proper function?

Part C: Comparisons to Other Proteins and Species

Use the BLAST tool on the protein websites to compare you protein sequence to other proteins and species. If you use NCBI, you can control the species name to get only other proteins within that species or leave it blank to get proteins in all species.
From the BLAST data, create a phylogenetic tree of different proteins with the organism and one relating the same protein in different species.
Use the ClustalW link on one of the websites to develop an amino acid sequence comparison and present this comparison.
Explore the Gene page for the underlying genomic DNA sequence as there is a large amount of basic information on this page relevant to the function and relationship with other proteins.
Identify interactions with other proteins, activities within the cell or biological functions (Gene Onotology, Biosystems, Pathways, etc.).
From the HomoloGene page identify the protein motifs found with in your protein and the level of conservancy of this protein across species.
How does a deeper understanding of primary amino acid sequence and identification of specific sequence motifs help identify the protein structure and function? Expand on the similarity of this protein to other proteins and the level of conservancy across species. How can this knowledge improve our understanding of the function and history of this protein? What can you learn about functions from identifying interactions between this protein and other proteins?

Part D: Conclusion/Discussion of the Protein

Expand on the role of this protein in known cellular and organismal mechanisms. What are some known disorders or diseases caused by abnormal structure and function of this protein? Speculate on some possible changes in protein structure and function that have not been identified or confirmed yet and how that abnormal structure could affect the functions of this protein in some future disease.

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Using one of the articles that you read for this class (it can be one posted in the class or one that you found) as a starting point, reflect on changes that you have or are currently experiencing. How can what you have learned in this class help you to develop your career and to navigate in this ever changing health care landscape? Remember, this is a reflection posting, there is not right or wrong answer. The goal is for you to look back at where you were when you began this class and where you are now – to reflect on the changes and growth that have occurred. Here are the course objectives to refresh your memory of what you have learned.

1. Analyze key leadership theories and concepts for relevance to healthcare organizations and nursing management.
2. Explore trends and issues relating to finance, human resources, performance improvement, and technology in various healthcare settings.
3. Examine the impact of organizational culture on individuals and groups within an institution.
4. Relate local, state, and national accrediting agency standards and outcome measures to the processes in selected healthcare environments

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This written assignment consists of a 3-4 page paper describing how nursing has evolved into a knowledge-based profession and how this contributes to supporting innovation in the workplace. APA format is required. Primary sources are preferred.

Please submit your paper as an attachment in a Word document

The following prompts are provided to guide the flow of the paper:

Introduce the concept of knowledge workers, and discuss how the changes in healthcare technology support the change of nursing from the role of caregiver (past) to critical thinker (future). Why are nurses as knowledge workers prepared to lead and support innovation?
How do the concepts of knowledge workers and innovation support other health initiatives, such as the IOM reports, the Patient Care Accountability and Affordability Act, Evidence-Based practice emphasis, and others? Tie in relevant initiatives you have studied in previous courses.
Discuss two or three steps you will personally make in the next two years to contribute to the professional initiatives you cited in the second prompt.

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Choose a current issue/trend topic from the following list: Technology in health care Collective bargaining The impaired nurse The global nurse workforce Mentoring and coaching in nursing The trimodal model of 21st-century effective nurse leaders Other instructor-approved topic Create a 6- to 8-page paper in APA format including a minimum of 4 to 5 references. Explain how you would lobby your legislators or local government for funds to support your issue or trend. Include the following elements in your paper: share why you chose the specific topic, the current relevance of material, how it is integrated into clinical practice, and how the information is used in clinical setting.

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The Discussion Board (DB) is part of the core of online learning. Classroom discussion in an online environment requires the active participation of students and the instructor to create robust interaction and dialogue. Every student is expected to create an original response to the open-ended DB question as well as engage in dialogue by responding to posts created by others throughout the week. At the end of each unit, DB participation will be assessed based on both level of engagement and the quality of the contribution to the discussion.

At a minimum, each student will be expected to post an original and thoughtful response to the DB question and contribute to the weekly dialogue by responding to at least two other posts from students. The first contribution must be posted before midnight (Central Time) on Wednesday of each week. Two additional responses are required after Wednesday of each week. Students are highly encouraged to engage on the Discussion Board early and often, as that is the primary way the university tracks class attendance and participation.

The purpose of the Discussion Board is to allow students to learn through sharing ideas and experiences as they relate to course content and the DB question. Because it is not possible to engage in two-way dialogue after a conversation has ended, no posts to the DB will be accepted after the end of each unit.

Background

For many years, antibiotics have been effectively used to treat bacterial disease; and pesticides have been used to protect our agricultural crops from many kinds of pests, including insects, worms (nematodes), fungi, or agricultural weeds, for example.

A growing concern for treating bacterial diseases or pest outbreaks is the evolution of antibiotic or pesticide resistance by bacterial or pest populations. Resistance means that a particular antibiotic is no longer effective in treating a disease, or that a particular pesticide will no longer prevent crop damage. This resistance can be viewed as evolution of a new trait at the population level, which is resistance to an antibiotic or to a pesticide. In this assignment, you will explore specific examples of antibiotic or pesticide resistance.

Assignment Details

Methicillin resistant Staphylococcus aureus (MRSA) has become a big concern in hospitals throughout the country and the world, as have other antibiotic resistant bacterial strains.

Part 1

The use, overuse, and abuse of antibiotics is accredited with creating these antibiotic resistant strains. Explain how this relates to natural selection.
Describe 1–2 of the things that people do (you can include individuals, doctors, health care professionals, hospitals, farmers, etc.) that contribute to this problem? Why?
Part 2

How can you prevent or slow down the spread and further the selection of new antibiotic resistant strains of bacteria?
Are there things that you can personally do to reduce your risk or even to reduce the spread of these dangerous microbes?
What is your reaction to the following sign that is commonly found in restrooms? Is it significant to the discussion of antibiotic resistance?

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